WDR48 (WD repeat domain 48) | Zendy

Anne OlazabalHerrero | Zendy; Godefridus J. Peters | Zendy; Elisa Giovannetti | Zendy; José A. Rodríguez | Zendy

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WDR48 (WD repeat domain 48)

Author(s) -

Anne OlazabalHerrero,

Godefridus J. Peters,

Elisa Giovannetti,

José A. Rodríguez

Publication year - 2018

Publication title -

atlas of genetics and cytogenetics in oncology and haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.121

H-Index - 2

ISSN - 1768-3262

DOI - 10.4267/2042/68759

Subject(s) - genetics , biology , computational biology , domain (mathematical analysis) , mathematics , mathematical analysis

WDR48 is a WD40-repeat containing protein that regulates the activity of three human deubiquitinating enzymes: USP1, USP12 and USP46. The best characterized role of WDR48 is regulation of the DNA damage response in complex with USP1. The USP1/WDR48 complex promotes deubiquitination of monoubiquitinated FANCD2 and monoubiquitinated PCNA, which are required in the regulation of translesion synthesis (TLS) and Fanconi anemia (FA) DNA repair pathways, respectively. In addition, in complex with USP12 and USP46, WDR48 regulates other important cellular processes such as synaptic transmission or signalling through the Akt, Notch and T-cell receptor pathways.

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