IRS2 (insulin receptor substrate 2) | Zendy

João Agostinho MachadoNeto | Zendy; Paula de Melo Campos | Zendy; Fabı́ola Traina | Zendy

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IRS2 (insulin receptor substrate 2)

Author(s) -

João Agostinho MachadoNeto,

Paula de Melo Campos,

Fabı́ola Traina

Publication year - 2018

Publication title -

atlas of genetics and cytogenetics in oncology and haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.121

H-Index - 2

ISSN - 1768-3262

DOI - 10.4267/2042/68156

Subject(s) - irs2 , insulin receptor , irs1 , insulin receptor substrate , biology , insulin , genetics , endocrinology , insulin resistance

Insulin receptor substrate 2 (IRS2) belongs to the insulin receptor substrate protein family and was initially discovered as an alternative route for signaling mediated by the insulin receptor. Currently, IRS2 has been well-established to mediate mitogenic and antiapoptotic signaling from several important cellular receptors. In the last years, many studies have indicated that IRS2 participates in the regulation of important biological processes involved in cancer phenotype, including cell proliferation, clonogenicity, metabolism and survival. The present review contains data on IRS2 DNA/RNA, protein encoded and function.

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