Nodular lymphocyte-predominant Hodgkin lymphoma

Diagnostic characteristics of nodular lymphocytepredominant Hodgkin lymphoma (NLPHL): nodular or nodular and diffuse proliferation of scattered lymphocyte predominant (LP) tumour cells within a background reminiscent of primary or secondary lymphoid follicles. Six different patterns: A) 'classical' nodular, B) serpiginous/interconnected nodular, C) nodular with prominent extra-nodular LP cells, D) T-cell-rich nodular, E) diffuse with a Tcell-rich background, and F) diffuse, B-cell-rich pattern. Typical histopathologic patterns in NLPHL include patterns A and B. Both of these patterns show a predominantly nodular growth, with LP cells located within the nodules. So called "histopathologic variants" are defined by prominent extranodular LP cells associated to patterns C to F. "Histopathologic variants" may be associated with advanced stage disease and higher relapse rate. Assessing "histopathologic variants" patterns in NLPHL may be useful for the management of the patients.