Lymphocyte-rich classical Hodgkin lymphoma

Lymphocyte-rich classical Hodgkin lymphoma accounts for a small fraction of all Hodgkin lymphomas. Lymphocyte-rich classical Hodgkin lymphoma is a rare variant of classical Hodgkin lymphoma which resembles nodular lymphocyte predominance Hodgkin lymphoma, in terms of nodular growth and lymphocyte-richness, and mimics cHL, in terms of the immunophenotype of the tumour cells. Lymphocyte-rich classical Hodgkin lymphoma tumour cells have lost the B-cell phenotype, but express CD30 and the B-cell transcription program. As regards to genetics and cytogenetics findings please refer to the general features described in the CARDS related to nodular lymphocyte predominance Hodgkin lymphoma and classical Hodgkin lymphoma.