SYK (spleen tyrosine kinase) | Zendy

Barnabas Nyesiga | Zendy; Anette Görloff Wingren | Zendy

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SYK (spleen tyrosine kinase)

Author(s) -

Barnabas Nyesiga,

Anette Görloff Wingren

Publication year - 2018

Publication title -

atlas of genetics and cytogenetics in oncology and haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.121

H-Index - 2

ISSN - 1768-3262

DOI - 10.4267/2042/66934

Subject(s) - syk , tyrosine kinase , cancer research , gene , spleen , biology , microbiology and biotechnology , genetics , immunology , signal transduction

Syk (Spleen tyrosine kinase) is an enzyme which in humans is encoded by the gene. Syk, along with Zap-70, is a member of the SYK Syk family of tyrosine kinases. Syk is known to have a crucial role in adaptive immune receptor signalling. Recent reports indicate that Syk also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. Syk is activated by C-type lectins and integrins, and activates new targets, including the CARD9-Bcl-10-MALT1 pathway and the NLRP3 inflammasome. Syk has a crucial role in autoimmune diseases and haematological malignancies.

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