Open AccessRAB31 (Ras-related protein in brain 31)
Author(s) -
Matthias Kotzsch,
Peter Goettig,
Susanne Soelch,
Viktor Magdolen
Publication year - 2018
Publication title -
atlas of genetics and cytogenetics in oncology and haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.121
H-Index - 2
ISSN - 1768-3262
DOI - 10.4267/2042/66072
Subject(s) - gene , genetics , biology
Rab31 is a member of the large Rab protein family (66 human members) of the Ras superfamily of small GTPases. Rab31 is expressed fairly ubiquitously in normal human tissue and regulates membrane traffic between the Golgi/TGN and the plasma membrane and/or endosomes. Dysregulated expression of Rab31 has not only been observed in several types of cancer, including breast, ovarian, cervical and liver cancer as well as glioblastoma, but also in skin diseases such as psoriasis and atopic dermatitis.
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