PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase, type II, alpha) | Zendy

Keli Lima | Zendy; João Agostinho MachadoNeto | Zendy

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PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase, type II, alpha)

Author(s) -

Keli Lima,

João Agostinho MachadoNeto

Publication year - 2018

Publication title -

atlas of genetics and cytogenetics in oncology and haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.121

H-Index - 2

ISSN - 1768-3262

DOI - 10.4267/2042/66053

Subject(s) - phosphatidylinositol , alpha (finance) , kinase , genetics , gene , biology , microbiology and biotechnology , medicine , construct validity , nursing , patient satisfaction

PIP4K2A is a lipid kinase that phosphorylates phosphatidylinositol (PtdIns) 5P, generating PtdIns4,5P2, which is an important precursor to second messengers of the phosphoinositide signal transduction pathways. Recently, studies have indicated that PIP4K2A is involved in the regulation of important biological processes that participate in the malignant phenotype, including cell proliferation, clonogenicity and survival. The present review on PIP4K2A contains data on DNA/RNA, protein encoded and where the gene is implicated.

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