CCDC6 (coiled-coil domain containing 6) | Zendy

Francesco Morra | Zendy; Caterina Miro | Zendy; Virginia Napolitano | Zendy; Francesco Merolla | Zendy; Angela Celetti | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

CCDC6 (coiled-coil domain containing 6)

Author(s) -

Francesco Morra,

Caterina Miro,

Virginia Napolitano,

Francesco Merolla,

Angela Celetti

Publication year - 2017

Publication title -

atlas of genetics and cytogenetics in oncology and haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.121

H-Index - 2

ISSN - 1768-3262

DOI - 10.4267/2042/62666

Subject(s) - coiled coil , genetics , domain (mathematical analysis) , biology , computational biology , microbiology and biotechnology , mathematics , mathematical analysis

CCDC6 gene product is a pro-apoptotic protein substrate of ATM whose loss or inactivation enhances tumor progression. In primary tumors the impaired function of CCDC6 protein has been ascribed to CCDC6 rearrangements, to somatic mutations and to CCDC6 different levels in several neoplasia. The CCDC6 turnover is regulated in a cell cycle dependent manner upon post-translational modification events. The impairment of CCDC6 turnover may affect cells behaviour and drug response.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research