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LDOC1 (leucine zipper, down-regulated in cancer 1) is expressed by a wide variety of normal human tissues but is downregulated in various kinds of human cancers. Epigenetic silencing by promoter hypermethylation was shown to be an important cause of LDOC1 down-regulation in oral, cervical and ovarian cancers. The normal physiological function of LDOC1 is still not clear. But the ability of LDOC1 to induce apoptosis in various kinds of human cancer cells suggests this gene may act as a tumor suppressor.