LDOC1 (leucine zipper, down-regulated in cancer 1) | Zendy

JennRen Hsiao | Zendy; JangYang Chang | Zendy

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LDOC1 (leucine zipper, down-regulated in cancer 1)

Author(s) -

JennRen Hsiao,

JangYang Chang

Publication year - 2017

Publication title -

atlas of genetics and cytogenetics in oncology and haematology

Language(s) - English

Resource type - Journals

ISSN - 1768-3262

DOI - 10.4267/2042/62505

Subject(s) - zipper , leucine zipper , genetics , cancer , atf3 , biology , gene , cancer research , transcription factor , computational biology , microbiology and biotechnology , computer science , gene expression , promoter , algorithm

LDOC1 (leucine zipper, down-regulated in cancer 1) is expressed by a wide variety of normal human tissues but is downregulated in various kinds of human cancers. Epigenetic silencing by promoter hypermethylation was shown to be an important cause of LDOC1 down-regulation in oral, cervical and ovarian cancers. The normal physiological function of LDOC1 is still not clear. But the ability of LDOC1 to induce apoptosis in various kinds of human cancer cells suggests this gene may act as a tumor suppressor.

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