Soft Tissues: Lipoblastoma with t(8;8)(q12;q12) RAB2A/PLAG1

Review on translocations in lipoblastoma with t(8;8)(q12;q12) RAB2A/PLAG1, with data on clinics, genetics and cytogenetics. Clinics and pathology Disease Is a rapidly growing, benign neoplasm. It is a mesenchymal tumor of fetal white fat tissue that appears most commonly in children under three years of age and affects males three times more often than females (McVay et al., 2006). It can present anywhere in the body, but is most commonly seen in the trunk and extremities. Surgical excision is usually curative, with a recurrence rate of about 20% (Jimenez, 1986; Hicks et al., 2001). Histologically, lipoblastoma shows a characteristic lobular architecture, with lobules containing lipoblasts embedded in a myxoid matrix, whereas lipoma is a tumor composed of only mature fat without lobulation (Weiss, 1996; Kuhnen et al., 2002; de Saint Aubain Somerhausen et al., 2008; Morerio et al., 2009).