CARD10 (caspase recruitment domain family, member 10)

Caspase recruitment domain family, member 10, CARD10 (also known as CARMA3 or Bimp1), is a member of the membrane-associated guanylate kinase (MAGUK) superfamily proteins that act to organize signaling at the plasma membrane. This family of proteins contains Src-homology 3 (SH3), PDZ, GuK domains and caspase recruitment domain (CARD). The amino-terminally located CARD of CARD10 functions as an activator of BCL10 and NF-kappaB (NF-kB) signaling critical for the regulation of cellular survival and proliferation. CARD10 (CARMA3) is reported to be overexpressed in various cancer types that include breast, glioma, colon and non-small-cell lung cancers. It appears that the over-expression of CARD10 correlates with tumor status positioning CARD10 as a novel therapeutic target for the treatment of various cancers.