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Platelet activation and functional changes were investigated in acute lymphoblastic leukemia (ALL) to provide the basis for early diagnosis and evaluation of curative effect. Platelet parameters, immature platelet fraction (IPF%), immature platelet count (IPC), P-selectin (CD62p) (PAC-1) expression were detected in ALL, ALL-complete remission-induced (CR1), and normal groups with an automatic blood cell analyzer and flow cytometer. CD62p and PAC-1 were higher in the ALL group before adenosine-5-diphosphate (ADP) activation than in the normal group (P &lt; 0.05); PAC-1 expression was higher and lower in the ALL-CR1 group than in normal and ALL groups (P &lt; 0.05), respectively. CD62p and PAC-1 expression was lower in the ALL group than in the normal group after ADP activation (P &lt; 0.05); PAC-1 expression was lower and higher in the ALL-CR1 group than in normal and ALL groups, respectively (P &lt; 0.05). Platelet count (PLT), mean platelet volume (MPV), platelet hematocrit (PCT), and platelet distribution width (PDW) were lower in the ALL group than in the ALL-CR1 group (P &lt; 0.05). PLT, MPV, and PCT did not differ between the ALL-CR1 group and the normal group (P &gt; 0.05). PDW did not differ statistically among all groups (P &gt; 0.05). IPF% and IPC values were higher and lower in the ALL group than in normal and ALL-CR1 groups (P &lt; 0.05), respectively. These did not differ significantly between the normal group and the ALL-CR1 group (P &gt; 0.05). Therefore, ALL patients demonstrate platelet activation and platelet dysfunction; platelet parameters and membrane glycoprotein expression can be used to evaluate the effect of ALL.

Platelet parameters and expression of platelet membrane glycoprotein in childhood acute lymphoblastic leukemia