Association analysis between the OPG g.27667T>A genetic variant and bone mineral density in Chinese postmenopausal women | Zendy

Jijun Zhao | Zendy; Donghai Feng | Zendy; Cheng Li | Zendy; T.M. Lu | Zendy; L. Wang | Zendy

Open Access

Association analysis between the OPG g.27667T>A genetic variant and bone mineral density in Chinese postmenopausal women

Author(s) -

Jijun Zhao,

Donghai Feng,

Cheng Li,

T.M. Lu,

L. Wang

Publication year - 2014

Publication title -

genetics and molecular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.356

H-Index - 48

ISSN - 1676-5680

DOI - 10.4238/2014.march.24.16

Subject(s) - bone mineral , femoral neck , osteoporosis , medicine , osteoprotegerin , genotype , bone density , postmenopausal women , endocrinology , gene , biology , genetics , receptor , activator (genetics)

The purpose of this study was to investigate the association of the g.27667T>A genetic variant in the osteoprotegerin (OPG) gene with bone mineral density (BMD) and osteoporosis. A total of 393 primary osteoporosis subjects and 402 healthy controls were recruited. The BMD of the femoral neck hip, lumbar spine (L2-4), and total hip were evaluated by Norland XR-46 dual-energy X-ray absorptiometry. The g.27667T>A genetic variant was genotyped using created restriction site-polymerase chain reaction. Our data indicated significant differences in BMD of the femoral neck hip, lumbar spine (L2-4), and total hip among different genotypes. Individuals with the genotype TT had significantly higher BMDs than those of genotypes TA and AA (P<0.05). Results from this study suggest that the g.27667T>A genetic variant in the OPG gene is potentially related to BMD and osteoporosis in Chinese postmenopausal women.

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