Genetic associations of the INSIG2 rs7566605 polymorphism with obesity-related metabolic traits in Malaysian Malays | Zendy

Yamunah Devi Apalasamy | Zendy; Foong Ming Moy | Zendy; Sanjay Rampal | Zendy; Awang Bulgiba | Zendy; Zahurin Mohamed | Zendy

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Genetic associations of the INSIG2 rs7566605 polymorphism with obesity-related metabolic traits in Malaysian Malays

Author(s) -

Yamunah Devi Apalasamy,

Foong Ming Moy,

Sanjay Rampal,

Awang Bulgiba,

Zahurin Mohamed

Publication year - 2014

Publication title -

genetics and molecular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.356

H-Index - 48

ISSN - 1676-5680

DOI - 10.4238/2014.july.4.4

Subject(s) - snp , single nucleotide polymorphism , obesity , biology , genetics , malay , genome wide association study , anthropometry , population , gene , bioinformatics , genotype , medicine , endocrinology , environmental health , linguistics , philosophy

A genome-wide association study showed that the tagging single nucleotide polymorphism (SNP) rs7566605 in the insulin-induced gene 2 (INSIG2) was associated with obesity. Attempts to replicate this result in different populations have produced inconsistent findings. We aimed to study the association between the rs7566605 SNP with obesity and other metabolic parameters in Malaysian Malays. Anthropometric and obesity-related metabolic parameters and DNA samples were collected. We genotyped the rs7566605 polymorphism in 672 subjects using real-time polymerase chain reaction. No significant associations were found between the rs7566605 tagging SNP of INSIG2 with obesity or other metabolic parameters in the Malaysian Malay population. The INSIG2 rs7566605 SNP may not play a role in the development of obesity-related metabolic traits in Malaysian Malays.

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