Association between single-nucleotide polymorphisms and milk production traits in buffalo | Zendy

Guilherme Costa Venturini | Zendy; Diércles F. Cardoso | Zendy; Fernando Baldi | Zendy; Ana Cláudia de Freitas | Zendy; R.R. Aspilcueta-Borquis | Zendy; Daniel Jordan de Abreu Santos | Zendy; Gregório Miguel Ferreira de Camargo | Zendy; Nedenia Bonvino Stafuzza | Zendy; Lúcia Galvão de Albuquerque | Zendy; Humberto Tonhati | Zendy

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Association between single-nucleotide polymorphisms and milk production traits in buffalo

Author(s) -

Guilherme Costa Venturini,

Diércles F. Cardoso,

Fernando Baldi,

Ana Cláudia de Freitas,

R.R. Aspilcueta-Borquis,

Daniel Jordan de Abreu Santos,

Gregório Miguel Ferreira de Camargo,

Nedenia Bonvino Stafuzza,

Lúcia Galvão de Albuquerque,

Humberto Tonhati

Publication year - 2014

Publication title -

genetics and molecular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.356

H-Index - 48

ISSN - 1676-5680

DOI - 10.4238/2014.december.4.20

Subject(s) - single nucleotide polymorphism , biology , genome wide association study , genetics , bubalus , snp , genetic association , quantitative trait locus , bovine genome , genome , gene , genotype , ecology

The aim of this study was to identify single-nucleotide polymorphisms (SNPs) in buffaloes associated with milk yield and content, in addition to somatic cell scores based on the cross-species transferability of SNPs from cattle to buffalo. A total of 15,745 SNPs were analyzed, of which 1562 showed 1% significance and 4742 with 5% significance, which were associated for all traits studied. After application of Bonferroni's correction for multiple tests of the traits analyzed, we found 2 significant SNPs placed on cattle chromosomes BTA15 and BTA20, which are homologous to buffalo chromosomes BBU16 and BBU19, respectively. In this genome association study, we found several significant SNPs affecting buffalo milk production and quality. Furthermore, the use of the high-density bovine BeadChip was suitable for genomic analysis in buffaloes. Although extensive chromosome arm homology was described between cattle and buffalo, the exact chromosomal position of SNP markers associated with these economically important traits in buffalo can be determined only through buffalo genome sequencing.

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