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Although  there have been several studies investigating a possible association between  essential hypertension and TSC gene Arg904Gln polymorphisms, the results  have been inconsistent. We conducted a meta-analysis of four case-control  studies (one study in Europe and three studies in Asia), including 1811  essential hypertension cases and 1381 controls. The pooled results showed no  significant associations between any of these polymorphisms  and essential hypertension (allele Arg vs allele Gln: odds ratio (OR) =  0.94, 95% confidence interval (95%CI) = 0.70-1.27), additive genetic model  (Arg/Arg vs Gln/Gln: OR = 0.98, 95%CI = 0.43-2.23), dominant genetic  model (Arg/Arg + Arg/Gln vs Gln/ Gln: OR = 0.97, 95%CI = 0.43-2.21), and  recessive genetic model (Arg/ Arg vs Arg/Gln + Gln/Gln: OR = 1.03, 95%CI  = 0.45-2.35). Based on the results of our meta-analysis, we conclude that the TSC gene Arg904Gln polymorphism is not associated with essential hypertension  risk.

Lack of an association between TSC gene Arg904Gln polymorphisms and essential hypertension risk based on a meta-analysis