Lack of an association between TSC gene Arg904Gln polymorphisms and essential hypertension risk based on a meta-analysis | Zendy

F. Zhang | Zendy; Yongjiao Yang | Zendy; Daiyu Hu | Zendy; HsienHsien Lei | Zendy; Y. Wang | Zendy

Open Access

Lack of an association between TSC gene Arg904Gln polymorphisms and essential hypertension risk based on a meta-analysis

Author(s) -

F. Zhang,

Yongjiao Yang,

Daiyu Hu,

HsienHsien Lei,

Y. Wang

Publication year - 2012

Publication title -

genetics and molecular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.356

H-Index - 48

ISSN - 1676-5680

DOI - 10.4238/2012.september.26.7

Subject(s) - essential hypertension , odds ratio , meta analysis , allele , confidence interval , genetic model , medicine , polymorphism (computer science) , genotype , genetics , bioinformatics , endocrinology , gene , biology , blood pressure

Although there have been several studies investigating a possible association between essential hypertension and TSC gene Arg904Gln polymorphisms, the results have been inconsistent. We conducted a meta-analysis of four case-control studies (one study in Europe and three studies in Asia), including 1811 essential hypertension cases and 1381 controls. The pooled results showed no significant associations between any of these polymorphisms and essential hypertension (allele Arg vs allele Gln: odds ratio (OR) = 0.94, 95% confidence interval (95%CI) = 0.70-1.27), additive genetic model (Arg/Arg vs Gln/Gln: OR = 0.98, 95%CI = 0.43-2.23), dominant genetic model (Arg/Arg + Arg/Gln vs Gln/ Gln: OR = 0.97, 95%CI = 0.43-2.21), and recessive genetic model (Arg/ Arg vs Arg/Gln + Gln/Gln: OR = 1.03, 95%CI = 0.45-2.35). Based on the results of our meta-analysis, we conclude that the TSC gene Arg904Gln polymorphism is not associated with essential hypertension risk.

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