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Although there is evidence suggesting genetic susceptibility  for keloids, studies investigating the association between Arg72Pro  polymorphism in the P53 gene and tendency to form keloids have given  variable results. We made a meta-analysis of the effects of P53 Arg72Pro  polymorphism on keloid risk in the Chinese population by conducting searches  of the published literature in Pubmed, Embase, CBMdisc, and CNKI databases up  to June 2011. Six studies were included in the meta-analysis, with a total of  359 keloid cases and 493 healthy controls. Meta-analysis results, respectively  in the PCR-reverse dot blot and PCR-RFLP subgroups, showed significant  associations between P53 Arg72Pro polymorphism and susceptibility to keloid in  the comparisons of Pro allele vs Arg allele (odds ratio (OR) = 2.29, 95%  confidence interval (CI) = 1.45-3.60; OR = 0.74, 95%CI = 0.56-0.98); Pro/Pro vs Pro/Arg + Arg/Arg (OR = 2.91, 95%CI = 1.88-4.53; OR = 0.54, 95%CI =  0.32-0.92); Pro/Pro vs Arg/Arg (OR = 2.79, 95%CI = 1.54-5.06; OR = 0.51,  95%CI = 0.28-0.92); Pro/Pro vs Pro/Arg (OR = 2.85, 95%CI = 1.75-4.63; OR  = 0.57, 95%CI = 0.32-0.99). We conclude that the Pro allele of P53 Arg72Pro  polymorphism is a risk factor for keloids in the Chinese population.

Meta-analysis demonstrates association between Arg72Pro polymorphism in the P53 gene and susceptibility to keloids in the Chinese population