A Large Animal Survival Model to Evaluate Bariatric Surgery Mechanisms | Zendy

Vlad V. Simianu | Zendy; Jonathan G. Sham | Zendy; Andrew S. Wright | Zendy; Skye D. Stewart | Zendy; Mouhamad Alloosh | Zendy; Michael Sturek | Zendy; David E. Cummings | Zendy; David R. Flum | Zendy

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A Large Animal Survival Model to Evaluate Bariatric Surgery Mechanisms

Author(s) -

Vlad V. Simianu,

Jonathan G. Sham,

Andrew S. Wright,

Skye D. Stewart,

Mouhamad Alloosh,

Michael Sturek,

David E. Cummings,

David R. Flum

Publication year - 2015

Publication title -

surgical science

Language(s) - English

Resource type - Journals

eISSN - 2157-9415

pISSN - 2157-9407

DOI - 10.4236/ss.2015.68050

Subject(s) - medicine , weight loss , obesity , diabetes mellitus , insulin resistance , surgery , metabolic syndrome , sham surgery , gastroenterology , physiology , endocrinology , pathology , alternative medicine

The impact of Roux-en-Y gastric bypass (RYGB) on type 2 diabetes mellitus is thought to result from upper and/or lower gut hormone alterations. Evidence supporting these mechanisms is incomplete, in part because of limitations in relevant bariatric-surgery animal models, specifically the lack of naturally insulin-resistant large animals. With overfeeding, Ossabaw swine develop a robust metabolic syndrome, and may be suitable for studying post-surgical physiology. Whether bariatric surgery is feasible in these animals with acceptable survival is unknown.

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