Solid Dose Form of Metformin with Ethyl Eicosapentaenoic Acid Does Not Improve Metformin Plasma Availability | Zendy

Jeffrey H. Burton | Zendy; William D. Johnson | Zendy; Frank L. Greenway | Zendy

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Solid Dose Form of Metformin with Ethyl Eicosapentaenoic Acid Does Not Improve Metformin Plasma Availability

Author(s) -

Jeffrey H. Burton,

William D. Johnson,

Frank L. Greenway

Publication year - 2016

Publication title -

pharmacology andamp pharmacy

Language(s) - English

Resource type - Journals

eISSN - 2157-9431

pISSN - 2157-9423

DOI - 10.4236/pp.2016.71005

Subject(s) - metformin , eicosapentaenoic acid , chemistry , pharmacology , medicine , organic chemistry , fatty acid , insulin , polyunsaturated fatty acid

The purpose of the study was to investigate effects of ethyl eicosapentaenoic acid on pharmacokinetics of metformin. Pharmacokinetic profiles of metformin and ethyl eicosapentaenoic acid when delivered separately or together in solid dose form were investigated and compared to determine whether the solid dose resulted in an altered metforminpharmacokinetics when given with or without food.

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