Open AccessDietary sugars inhibit biologic functions of the pattern recognition molecule, mannose-binding lectin
Author(s) -
Kazue Takahashi,
WeiChuan Chang,
Patience Moyo,
Mitchell R. White,
Parool Meelu,
Anamika Verma,
Gregory L. Stahl,
Kevan L. Hartshorn,
Vijay Yajnik
Publication year - 2011
Publication title -
open journal of immunology
Language(s) - English
Resource type - Journals
eISSN - 2162-4526
pISSN - 2162-450X
DOI - 10.4236/oji.2011.12005
Subject(s) - mannan binding lectin , lectin pathway , innate immune system , ficolin , lectin , complement system , biology , microbiology and biotechnology , collectin , mannose , pattern recognition receptor , immune system , c type lectin , influenza a virus , immunology , classical complement pathway , biochemistry , virus
Mannose-binding lectin (MBL), a mammalian lectin, is a pattern recognition molecule of the innate immune system and recognizes carbo-hydrates that are exposed on pathogens. In this study, we observed that fructose down regu-lates MBL-mediated innate immune mechanisms against both influenza A virus (IAV) and Staphy-lococcus aureus. These mechanisms include the lectin complement pathway and coagulation enzyme-like activities on both pathogens. Fur-thermore, fructose also reduces MBL-mediated phagocytosis of S. aureus and IAV and MBL- mediated IAV infection to epithelial cells. In contrast, sucrose inhibits MBL-mediated im-mune mechanisms against S. aureus but not IAV. Together, our studies show that dietary sugars, in particular fructose, negatively regulate the innate immunity against viral and bacterial pathogens
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