Novel 1,3,4-(thiadiazol-2-ylamino) methyl-5-(pyridin-4-yl)-1,3,4-oxadiazol-2-thiones: synthesis, docking and antimycobacterial testing | Zendy

Trupti S. Chitre | Zendy; Santosh Panda | Zendy; Shital Patil | Zendy; Aparna S. Chothe | Zendy; G. Vignesh | Zendy; M. K. Kathiravan | Zendy

Open Access

Novel 1,3,4-(thiadiazol-2-ylamino) methyl-5-(pyridin-4-yl)-1,3,4-oxadiazol-2-thiones: synthesis, docking and antimycobacterial testing

Author(s) -

Trupti S. Chitre,

Santosh Panda,

Shital Patil,

Aparna S. Chothe,

G. Vignesh,

M. K. Kathiravan

Publication year - 2011

Publication title -

advances in biological chemistry

Language(s) - English

Resource type - Journals

eISSN - 2162-2191

pISSN - 2162-2183

DOI - 10.4236/abc.2011.12002

Subject(s) - antimycobacterial , docking (animal) , chemistry , isoniazid , stereochemistry , mycobacterium tuberculosis , combinatorial chemistry , tuberculosis , medicine , nursing , pathology

In the present study, a novel series of Mannich bases of 3-substituted 5-(pyridin-4-yl)-1,3, 4-oxadiazol-2-thione derivatives were synthesized. Docking study was performed to rationalize the possible interactions between the synthesized com-pounds and active site of 14DM. The test compounds were screened for antimycobacterial activity using Middlebrook 7H9 medium against M. tuberculosis H37Rv (ATCC 27294) as well as Isoniazid (INH) resistant clinical strain. Among the series 5c and 5a are found to be most potent (susceptible) while the compound 5f did not show activity against M. tuberculosis H37Rv (resistant). The SAR study reveals the importance of substitutions at para position for good activity

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