Characteristics of 5-Hydroxytryptamine Receptors Involved in Contraction of Feline Ileal Longitudinal Smooth Muscle | Zendy

Yiyi Wang | Zendy; Sun Young Park | Zendy; Kyung Hoon Oh | Zendy; Youngsil Min | Zendy; Yunjeong Lee | Zendy; SeokYong Lee | Zendy; Uy Dong Sohn | Zendy

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Characteristics of 5-Hydroxytryptamine Receptors Involved in Contraction of Feline Ileal Longitudinal Smooth Muscle

Author(s) -

Yiyi Wang,

Sun Young Park,

Kyung Hoon Oh,

Youngsil Min,

Yunjeong Lee,

SeokYong Lee,

Uy Dong Sohn

Publication year - 2011

Publication title -

korean journal of physiology and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.514

H-Index - 29

eISSN - 2093-3827

pISSN - 1226-4512

DOI - 10.4196/kjpp.2011.15.5.267

Subject(s) - ketanserin , methysergide , contraction (grammar) , muscle contraction , receptor , medicine , endocrinology , 5 ht receptor , receptor antagonist , serotonin , guanethidine , 5 ht2 receptor , chemistry , prazosin , agonist , pharmacology , antagonist , stimulation

A number of studies have demonstrated that 5-hydroxytryptamine (5-HT) can induce muscle contraction or relaxation response and enhance secretion in the gastrointestinal tract via a multiplicity of 5-HT receptor subtypes. In the present study, we investigated the pharmacological characterization of the 5-HT-induced contractile response in longitudinal smooth muscle isolated from the feline ileum. Addition of 5-HT into muscle chambers enhanced the basal tone and spontaneous activity in a concentration-dependent manner. The neurotoxin tetrodotoxin did not alter the 5-HT-induced contraction of the longitudinal muscles. Neither atropine nor guanethidine affected the contraction. The 5-HT agonists, 5-methylserotonin hydrochloride and mosapride, also evoked concentration-dependent contractions. The 5-HT-induced contraction was enhanced by the 5HT(2) receptor antagonist ketanserin and the 5-HT(3) receptor antagonist ondansetron but was inhibited by the 5-HT(1) receptor antagonist methysergide and 5-HT(4) receptor antagonist GR113808. These results indicate that 5-HT(1) and 5-HT(4) receptors may mediate the contraction of the 5-HT-induced response and 5-HT(2) and 5-HT(3) receptors may mediate 5-HT-induced relaxation in feline ileal longitudinal smooth muscles.

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