Open AccessRegulation of DREAM Expression by Group I mGluR
Author(s) -
Jinu Lee,
InSook Kim,
So Ra Oh,
Suk Jin Ko,
Mi Kyung Lim,
Dong Goo Kim,
Chul Hoon Kim
Publication year - 2011
Publication title -
korean journal of physiology and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 29
eISSN - 2093-3827
pISSN - 1226-4512
DOI - 10.4196/kjpp.2011.15.2.95
Subject(s) - metabotropic glutamate receptor , metabotropic glutamate receptor 1 , dream , repressor , microbiology and biotechnology , chemistry , dynorphin , regulator , biology , neuroscience , agonist , gene expression , receptor , biochemistry , gene , opioid , opioid peptide
DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom