Open AccessProteomics Analysis of Brain Meningiomas in Pursuit of Novel Biomarkers of the Aggressive Behavior
Author(s) -
Garni Barkhoudarian,
Julian P. Whitelegge,
Daniel F. Kelly,
Margaret Simonian
Publication year - 2016
Publication title -
journal of proteomics and bioinformatics
Language(s) - English
Resource type - Journals
ISSN - 0974-276X
DOI - 10.4172/jpb.1000389
Subject(s) - proteomics , meningioma , multiplex , malignancy , computational biology , malignant transformation , transformation (genetics) , bioinformatics , medicine , biology , pathology , biochemistry , gene
The aim of this pilot study was to evaluate the use of advanced proteomics techniques to identify novel protein markers that contribute to the transformation of benign meningiomas to more aggressive and malignant subtypes. Multiplex peptide stable isotope dimethyl labelling and nano-LCMS was used to identify and quantify the differentially expressed proteins in WHO Grade I, II and III meningioma tissues. The proteins identified will help elucidate the process of transformation to malignancy and may contribute to improved diagnosis and treatment of these aggressive tumors.