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The purpose of present investigation was to develop the dosage form containing metformin for both immediate and sustained release. The SR release tablets of metformin were not useful to control the fasting glucose levels whereas conventional metformin tablets cannot acts for prolonged time, But the tablets prepared by present method useful for control both fasting glucose levels and maintenance dose. Even though many combination therapies available in market as metformin for sustain release and other sulfonylureas for immediate release, The primary concern for considering metformin hydrochloride as monotherapy was its efficient activity, less cost and negligible cardiac risk factors. The immediate release dose was developed by direct compression method and sustained release beads were prepared by inotropic gelation method using sodium alginate and sodium CMC, CaCl2. The various batches of directly compressed tablets with different percentages of sustained release beads were prepared and evaluated for various physical properties and dissolution profile. Hardness (kg/cm2) of tablets was decreased and percentage loss in friability is increased as concentration of beads in tablet increased. All the parameters are within range for tablets containing micro beads up to 35% thereafter loss in friability and Hardness (kg/cm2) are not within range.

Preparation and In-vitro Evaluation of Metformin HCl Tablets Containing Sustained Release Beads for Increasing Therapeutic Window