Open AccessThe Persistent Neurotoxic Effects of Methamphetamine on Dopaminergic and Serotonergic Markers in Male and Female Rats
Author(s) -
Lisa M. McFadden,
Paula L. Vieira-Brock
Publication year - 2016
Publication title -
toxicology: open access
Language(s) - English
Resource type - Journals
ISSN - 2476-2067
DOI - 10.4172/2476-2067.1000116
Subject(s) - meth , methamphetamine , serotonergic , dopaminergic , neurochemical , medicine , hippocampus , endocrinology , striatum , neurotoxicity , dopamine , hyperthermia , dopamine transporter , serotonin , serotonin transporter , psychology , toxicity , chemistry , receptor , monomer , organic chemistry , acrylate , polymer
Methamphetamine (METH) is a highly addictive substance abused world-wide in both males and females. Preclinical studies in male rodents suggest that large-dose exposure to METH can lead to persistent neurotoxic consequences to various brain regions. However, little research has focused on the potential role of sex in the neurotoxic consequences of METH exposure.