Open AccessModeling Causal Relationships among Brain Areas in the Mesocorticolimbic System during Resting-State in Cocaine Users Utilizing a Graph Theoretic Approach
Author(s) -
Suchismita Ray,
Bharat B. Biswal,
Ashley Aya,
Suril Gohel,
Aradhana Srinagesh,
Catherine Hanson,
Stephen José Hanson
Publication year - 2017
Publication title -
journal of alcohol drug dependence
Language(s) - English
Resource type - Journals
ISSN - 2329-6488
DOI - 10.4172/2329-6488.1000279
Subject(s) - resting state fmri , ventral tegmental area , neuroscience , prefrontal cortex , psychology , orbitofrontal cortex , ventral striatum , anterior cingulate cortex , midbrain , limbic system , striatum , dorsolateral prefrontal cortex , posterior cingulate , retrosplenial cortex , cortex (anatomy) , central nervous system , dopamine , cognition , dopaminergic
While effective connectivity (EC, causal interaction) between brain areas has been investigated in chronic users of cocaine as they view cocaine pictures cues, no study has examined EC while they take part in a resting-state scan. This resting-state fMRI study aims to investigate the causal interaction among brain areas in the mesocorticolimbic system (MCLS), which is involved in reward and motivation, in cocaine users (vs. controls).