Open AccessFibroblast Growth Factor 19 Activates the Unfolded Protein Response and Mitogen-Activated Protein Kinase Phosphorylation in H-69 Cholangiocyte Cells
Author(s) -
Hannan A. Qureshi,
Jeffrey Pearl,
Kristy A. Anderson,
Richard M. Green
Publication year - 2014
Publication title -
journal of liver
Language(s) - English
Resource type - Journals
ISSN - 2167-0889
DOI - 10.4172/2167-0889.1000158
Subject(s) - fgf19 , mapk/erk pathway , cholangiocyte , protein kinase a , biology , fibroblast growth factor , cancer research , microbiology and biotechnology , kinase , medicine , endocrinology , biochemistry , receptor
Cholangiocytes are injured in many biliary tract diseases that result in cirrhosis, cholangiocarcinoma and need for liver transplantation. Recent studies demonstrate that the hormone Fibroblast Growth Factor 19 (FGF19) is produced in the ileum and regulates hepatic gene expression via the enterohepatic circulation. However, the role of FGF19 on cholangiocytes remains largely unknown. The purpose of this study was to elucidate the effect of FGF19 on cholangiocyte gene and protein expression.