Open AccessMethods for an International Randomized Clinical Trial to Investigate the Effect of Gsk249320 on Motor Cortex Neurophysiology using Transcranial Magnetic Stimulation in Survivors of Stroke
Author(s) -
Matthew P. Malcolm,
Lori Enney,
Steven C. Cramer
Publication year - 2014
Publication title -
journal of clinical trials
Language(s) - English
Resource type - Journals
ISSN - 2167-0870
DOI - 10.4172/2167-0870.1000199
Subject(s) - standardization , transcranial magnetic stimulation , clinical trial , medicine , protocol (science) , physical medicine and rehabilitation , clinical neurophysiology , stroke (engine) , neuroimaging , randomized controlled trial , medical physics , computer science , psychiatry , electroencephalography , surgery , pathology , alternative medicine , stimulation , mechanical engineering , engineering , operating system
Transcranial Magnetic Stimulation (TMS) is a neurophysiological tool capable of assessing the motor nervous system and its change over time. In multi-site clinical trials, this technique has some advantages over other neuroimaging methods owing to its relatively low cost, low personnel and equipment infrastructure requirements, and greater ease in consistently applying technology to collect and analyze data. Limited published details exist regarding methods to deliver TMS and analyze data in a standardized and consistent manner as part of an international, multicenter, clinical trial.