Open AccessLong-Term Chamomile Therapy of Generalized Anxiety Disorder: A Study Protocol for a Randomized, Double-Blind, Placebo- Controlled Trial
Author(s) -
Jun J. Mao,
Susan Q. Li,
Irene Soeller,
Kenneth Rockwell,
Sharon X. Xie,
Jay D. Amsterdam
Publication year - 2015
Publication title -
journal of clinical trials
Language(s) - English
Resource type - Journals
ISSN - 2167-0870
DOI - 10.4172/2167-0870.1000188
Subject(s) - medicine , anxiolytic , anxiety , randomized controlled trial , placebo , adverse effect , clinical trial , music therapy , generalized anxiety disorder , antidepressant , psychiatry , alternative medicine , pathology
Anxiety symptoms are among the most common reasons for consumers to use Complementary and Alternative Medicine (CAM) therapy. Although many botanicals have been proposed as putative remedies for anxiety symptoms, there has been a paucity of controlled trials of these remedies. A preliminary study of the anxiolytic effect of Chamomile ( Matricaria recutita ) in humans suggests that chamomile may have anxiolytic and antidepressant activity. We now seek to conduct a 5-year randomized, double-blind, placebo-substitution study to examine the short and long-term safety and efficacy of chamomile extract in Generalized Anxiety Disorder (GAD).