Open AccessEffect of Intra-Medullar and Intra-Venous Infusions of Mesenchymal Stem Cells on Cell Engraftment by In-Vivo Cell Tracking and Osteoinductivity in Rabbit Long Bones: A Pilot Study
Author(s) -
Akikazu Ishihara
Publication year - 2014
Publication title -
orthopedic and muscular system :
Language(s) - English
Resource type - Journals
ISSN - 2161-0533
DOI - 10.4172/2161-0533.1000172
Subject(s) - medicine , mesenchymal stem cell , bone mineral , cancellous bone , in vivo , tibia , long bone , anatomy , pathology , osteoporosis , biology , microbiology and biotechnology
Stem cell therapy can be an efficacious treatment option for bone fragility disorders (eg, osteogenesis imperfecta, disuse osteopenia, and osteoporosis), and successful cell therapy application may be dependent on optimal cell engraftment in target bones. The objective of this study was to compare the efficiency of intra-medullar and intra-venous delivery of mesenchymal stem cells (MSC) to improve cell engraftment rate, bone mineral density, and micro-architecture.