Open AccessDifferential Cytokine Levels in Adults Induced by a Novel Candidate TB Boost Vaccine, MVA85A-According to Previous BCG Vaccination Status
Author(s) -
Patrick K. Owiafe
Publication year - 2012
Publication title -
journal of vaccines and vaccination
Language(s) - English
Resource type - Journals
ISSN - 2157-7560
DOI - 10.4172/2157-7560.1000158
Subject(s) - vaccination , medicine , immunology , bcg vaccine , virology , cytokine , tuberculosis vaccines , immunopharmacology , tuberculosis , immune system , mycobacterium tuberculosis , pathology
MVA85A is a candidate boost vaccine for TB. A previously reported study showed no differences in response to MVA85A in 10 BCG vaccinated (BCG+) and 11 BCG naive (BCG-) adult Gambians. Here we evaluated the effect of pre-existing plasma cytokines in both groups before and after MVA85A vaccination on the vaccine-induced immune response. Pre-vaccination levels of IL-8 were higher in BCG+ subjects, whilst MCP-1 levels were lower compared to BCG-. Following MVA85A vaccination, concentrations of IL-8, IL-18, IL-12(p70) and MCP-1 were differentially induced between BCG+ and BCG- groups. The implications of these findings depend on their role in TB pathogenesis. © 2012 Owiafe PK, et al