Open AccessTowards Real-time Metabolic Profiling of Cancer with Hyperpolarized Succinate
Author(s) -
Nikolaos Zacharias,
Christopher McCullough
Publication year - 2016
Publication title -
journal of molecular imaging and dynamics
Language(s) - English
Resource type - Journals
ISSN - 2155-9937
DOI - 10.4172/2155-9937.1000123
Subject(s) - hyperpolarization (physics) , chemistry , in vivo , citric acid cycle , metabolism , cancer cell , cancer research , oxidative phosphorylation , metabolic pathway , biochemistry , biodistribution , cancer , in vitro , nuclear magnetic resonance spectroscopy , biology , medicine , stereochemistry , microbiology and biotechnology
The energy-yielding mitochondrial Krebs cycle has been shown in many cancers and other diseases to be inhibited or mutated. In most cells, the Krebs cycle with oxidative phosphorylation generates approximately 90% of the adenosine triphosphate in the cell. We designed and hyperpolarized carbon-13 labeled succinate (SUC) and its derivative diethyl succinate (DES) to interrogate the Krebs cycle in real-time in cancer animal models.