Optimal Group Sequential Designs and Related (In Clinical Trials)

I have implemented many adaptive design methods using R or SAS, compared them via simulations, have a manuscript under journal review process on a new combination test for designing a two-stage adaptive design. Additionally, I am interested in topics in this area as follows: 1) comments on regulatory guidance documents on adaptive designs ; 2) considerations and optimization of adaptive trial design in clinical development; 3) optimal cost-effective go-no go decisions in clinical development; 4) timing and frequency of interim analyses; 5) approaches for optimal dose selection for adaptive designs; 6) randomization challenges in adaptive design studies; 7) implementing issues; 8) approaches for patient recruitment modeling and simulation.