Open AccessHigh Protein/Fish Oil Diet Prevents Hepatic Steatosis in NONcNZO10 Mice; Association with Diet/Genetics-regulated Micro-RNAs
Author(s) -
Nikhil Adi,
Jennipher Adi,
Roberta M. LassanceSoares,
Paul Kurlansky,
Hong Yu,
Keith A. Webster
Publication year - 2016
Publication title -
journal of diabetes and metabolism
Language(s) - English
Resource type - Journals
ISSN - 2155-6156
DOI - 10.4172/2155-6156.1000676
Subject(s) - steatosis , fatty acid synthase , endocrinology , medicine , adiponectin , biology , peroxisome proliferator activated receptor , fatty liver , fatty acid binding protein , lipid metabolism , insulin resistance , insulin , receptor , biochemistry , gene , disease
NONcNZO10 (NZ10) mice are predisposed to obesity and develop type 2 diabetes (T2D) and hepatic steatosis even when maintained on a control diet (CD) of 6% fat. Studies were designed to determine whether this extreme susceptibility phenotype could be alleviated by diet and if so the molecular targets of diet.