Open AccessMicroarrays-Enabled Hypothesis Generation: The Suspect Role of FNBP-1 in Neuropsychiatric Pathogenesis Associated with HIV and/or HCVInfection
Author(s) -
Antonios Katsounas,
Wilting Kr,
Lempicki Ra,
Joerg F. Schlaak,
Guido Gerken
Publication year - 2016
Publication title -
journal of aids and clinical research
Language(s) - English
Resource type - Journals
ISSN - 2155-6113
DOI - 10.4172/2155-6113.1000641
Subject(s) - microarray , medicine , microarray analysis techniques , fold change , hepatitis c virus , gene chip analysis , hepatitis c , pathogenesis , dna microarray , immunology , gene , gene expression , biology , virus , genetics
The spectrum of neuropsychiatric illness (NI) associated with the Human Immunodeficiency Virus (HIV) and/or the Hepatitis C Virus (HCV) is far reaching and significantly impacts the clinical presentation and outcome of infected persons; however, the etiological and pathophysiological background remains partially understood. The present work was aimed to investigate the potential significance of formin binding protein 1 (FNBP-1)-dependent pathways in NI-pathogenesis by elaborating on previous microarray-based research in HIV and/or HCV-infected patients receiving interferon-α (IFN-α) immunotherapy via a rigorous data mining procedure.