Open AccessEffect of CBT on Depressive Symptoms in Methadone Maintenance Patients Undergoing Treatment for Hepatitis C
Author(s) -
Susan E. Ramsey,
Patricia A. Engler,
Michael D. Stein,
Richard A. Brown,
Patricia A. Cioe,
Christopher W. Kahler,
Kittichai Promrat,
Jennifer Rose,
James R. Anthony,
David A. Solomon
Publication year - 2011
Publication title -
journal of addiction research and therapy
Language(s) - English
Resource type - Journals
ISSN - 2155-6105
DOI - 10.4172/2155-6105.1000109
Subject(s) - depression (economics) , medicine , methadone , methadone maintenance , chronic hepatitis , hepatitis c , depressive symptoms , randomized controlled trial , antiviral treatment , psychiatry , intervention (counseling) , antiviral therapy , clinical psychology , cognition , immunology , virus , economics , macroeconomics
To examine the efficacy of a cognitive-behavioral intervention (CBT) to prevent depression among methadone maintenance patients undergoing antiviral treatment for hepatitis C (HCV), 29 patients beginning HCV treatment were randomized to CBT or standard care (SC). Study participants did not meet criteria for major depressive disorder at the time of study recruitment. CBT did not result in less depression-related antiviral treatment failure, better adherence to antiviral treatment, or better HCV RNA outcomes. There were no significant treatment group differences on depressive symptoms over time. The CBT group did display a greater and more consistent decline in both BDI-II and HAM-D scores over time (d=.85 on the BDI-II; d=.72 on the HAM-D).