Open AccessmiR-203 Functions as a Tumor Suppressor by Inhibiting Epithelial to Mesenchymal Transition in Ovarian Cancer
Author(s) -
Guannan Zhao,
Yuqi Guo,
Zixuan Chen,
Yinan Wang,
Chuanhe Yang,
Andrew Dudas,
Ziyun Du,
Wen Li,
Yu Zou,
Erzsébet Szabó,
Sue-Chin Lee,
Michelle Sims,
Wei Gu,
T. Tillmanns,
Lawrence M. Pfeffer,
Gábor Tigyi,
Junming Yue
Publication year - 2015
Publication title -
journal of cancer science and therapy
Language(s) - English
Resource type - Journals
ISSN - 1948-5956
DOI - 10.4172/1948-5956.1000322
Subject(s) - ovarian cancer , cancer research , gene silencing , microrna , epithelial–mesenchymal transition , cancer , small hairpin rna , cell growth , ovarian carcinoma , biology , ovarian tumor , downregulation and upregulation , matrigel , metastasis , medicine , cell culture , gene knockdown , gene , angiogenesis , biochemistry , genetics
Ovarian cancer is a gynecological malignancy that has a high mortality rate in women due to metastatic progression and recurrence. miRNAs are small, endogenous, noncoding RNAs that function as tumor suppressors or oncogenes in various human cancers by selectively suppressing the expression of target genes. The objective of this study is to investigate the role of miR-203 in ovarian cancer.