Mitogen-activated Protein Kinase Signaling in Inflammation-related Carcinogenesis | Zendy

Zahid Manzoor | Zendy; Jung Eun Koo | Zendy; YoungSang Koh | Zendy

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Mitogen-activated Protein Kinase Signaling in Inflammation-related Carcinogenesis

Author(s) -

Zahid Manzoor,

Jung Eun Koo,

YoungSang Koh

Publication year - 2014

Publication title -

journal of bacteriology and virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.179

H-Index - 12

eISSN - 2093-0429

pISSN - 1598-2467

DOI - 10.4167/jbv.2014.44.4.297

Subject(s) - inflammation , carcinogenesis , kinase , mapk/erk pathway , signal transduction , microbiology and biotechnology , protein kinase a , cancer research , mitogen activated protein kinase , biology , cancer , immunology , genetics

The role of mitogen-activated protein kinases (MAPKs) in regulation of inflammation is well known. MAPK family is activated by various stimuli and involved in transmitting extracellular signals to nucleus leading to gene regulation. Inflammation is primary defensive response of host against microbes. Controlled inflammation is helpful and indispensable for host defense. However, uncontrolled inflammatory response leads to various inflammatory diseases and cancer. Persistent inflammation leads to cell proliferation and survival that plays crucial role in tumorigenesis. In this review, we recapitulate the recent knowledge of MAPK signaling and its roles in inflammation-associated carcinogenesis.

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