Human Adenovirus Type 5 as a Delivery Vector is Not Neutralized in Field Serum Samples of Cattle, Pig, and Goat of Republic of Korea | Zendy

Su-Mi Kim | Zendy; Hyang-Sim Lee | Zendy; KwangNyeong Lee | Zendy; Jong-Hyeon Park | Zendy; Young-Joon Ko | Zendy; Byounghan Kim | Zendy

Open Access

Human Adenovirus Type 5 as a Delivery Vector is Not Neutralized in Field Serum Samples of Cattle, Pig, and Goat of Republic of Korea

Author(s) -

Su-Mi Kim,

Hyang-Sim Lee,

KwangNyeong Lee,

Jong-Hyeon Park,

Young-Joon Ko,

Byounghan Kim

Publication year - 2014

Publication title -

journal of bacteriology and virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.179

H-Index - 12

eISSN - 2093-0429

pISSN - 1598-2467

DOI - 10.4167/jbv.2014.44.3.269

Subject(s) - titer , livestock , virology , biology , antibody , virus , veterinary medicine , vector (molecular biology) , antibody titer , immunology , medicine , gene , recombinant dna , genetics , ecology

Human adenovirus type 5 (hAd5) vectors have been demonstrated to be useful vehicles for gene expressions in animals. However, it has not been reported whether hAd5 transduction might be hampered in the sera of livestock animals in Republic of Korea. We collected 205 samples of livestock animals, such as pig (n=84), cattle (n=84), and goat (n=37) in Korea. The neutralizing antibody (NAb) titers to hAd5 virus were less than 15 in most of samples. Only 8% of goat samples had a NAb titer of 15 or 30. Thus, we showed that hAd5 virus was not neutralized in sera from cattle, pig, and goat, and suggest that the hAd5 vector could be used for the effective delivery of vaccines or proteins in livestock animals in the field.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research