Stabilizing Microtubular Network Facilitates the Intracellular Growth ofOrientia tsutsugamushi | Zendy

Mee Kyoung Kim | Zendy; MiJeong Kim | Zendy; ByungUk Lim | Zendy; JaeSeung Kang | Zendy

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Stabilizing Microtubular Network Facilitates the Intracellular Growth ofOrientia tsutsugamushi

Author(s) -

Mee Kyoung Kim,

MiJeong Kim,

ByungUk Lim,

JaeSeung Kang

Publication year - 2006

Publication title -

journal of bacteriology and virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.179

H-Index - 12

eISSN - 2093-0429

pISSN - 1598-2467

DOI - 10.4167/jbv.2006.36.2.51

Subject(s) - microtubule , microtubule organizing center , colchicine , cytoplasm , intracellular , microbiology and biotechnology , biology , chemistry , cell , centrosome , biochemistry , cell cycle , genetics

Microtubule network provides many intracellular microbes with an efficient way to move within host cells. Orientia tsutsugamushi move from the cell periphery to the microtubule organizing center (MTOC) by dynein-dependent mechanism. In this study, we investigated the role of microtubule on the growth of O. tsutsugamushi. The treatment of infected cells with taxol as well as daunomycin enhanced the bacterial growth in contrast to colchicine. Immunofluorescent (IF) staining of taxol-treated cells exhibited that O. tsutsugamushi clustered tightly near the nucleus with thick bundles of microtubules, whereas dispersed in the cytoplasm in colchicine-treated cells. These results suggest that microtubule network facilitate the growth of O. tsutsugamushi.

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