Atorvastatin Induces FXR and CYP7A1 Activation as a Result of the Sequential Action of PPARγ/PGC-1α/HNF-4α in Hep3B Cells | Zendy

Jin Lee | Zendy; Eun Mi Hong | Zendy; Jang Han Jung | Zendy; Se Woo Park | Zendy; Sang Pyo Lee | Zendy; Dong Hee Koh | Zendy; Hyun Joo Jang | Zendy; Sea Hyub Kae | Zendy

Open Access

Atorvastatin Induces FXR and CYP7A1 Activation as a Result of the Sequential Action of PPARγ/PGC-1α/HNF-4α in Hep3B Cells

Author(s) -

Jin Lee,

Eun Mi Hong,

Jang Han Jung,

Se Woo Park,

Sang Pyo Lee,

Dong Hee Koh,

Hyun Joo Jang,

Sea Hyub Kae

Publication year - 2021

Publication title -

korean journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.203

H-Index - 25

eISSN - 2233-6869

pISSN - 1598-9992

DOI - 10.4166/kjg.2020.156

Subject(s) - atorvastatin , farnesoid x receptor , cholesterol 7 alpha hydroxylase , peroxisome proliferator activated receptor , gene silencing , pregnane x receptor , troglitazone , pharmacology , chemistry , medicine , endocrinology , receptor , nuclear receptor , transcription factor , biochemistry , gene

PPARγ, farnesoid X receptor (FXR) and CYP7A1 are associated with solubility of bile. This study was performed to understand a mechanism and interactions of statin-induced PPARγ, PGC-1α and HNF-4α related to the statin-induced activation of FXR and CYP7A1, and verify whether the mevalonate pathway is involved in the mechanism.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research