Open AccessDNA Double Strand Breaks in Gastric Epithelium withHelicobacter pyloriInfection
Author(s) -
Young Jun Chang,
Sangwon Byun,
Hyung Keun Kim,
Young Seok Cho,
Sung Soo Kim,
Jin Il Kim,
Jae Kwang Kim,
Eun Sun Jung
Publication year - 2012
Publication title -
korean journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.203
H-Index - 25
eISSN - 2233-6869
pISSN - 1598-9992
DOI - 10.4166/kjg.2012.60.2.79
Subject(s) - helicobacter pylori , epithelium , dna damage , gastritis , dna fragmentation , gastric mucosa , chronic gastritis , fragmentation (computing) , stomach , apoptosis , medicine , biology , pathology , microbiology and biotechnology , dna , programmed cell death , gastroenterology , genetics , ecology
DNA double strand breaks (DSB) is one of the critical types of DNA damage. If unrepaired, DSB is accumulated in the nucleus of cells, the cells become apoptotic or transform to tumor by way of genomic instability. Some of malignant cancers and its premalignant lesions were proven to have DSB in their nuclei. There was no report that Helicobacter pylori (H. pylori), the gastric carcinogen, induce DNA DSB in gastric epithelium in vivo. The aim of this study was to investigate whether H. pylori induce DSB in the gastric epithelial cells of chronic gastritis.
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