Wheatgrass extract inhibits hypoxia-inducible factor-1-mediated epithelial-mesenchymal transition in A549 cells | Zendy

Nam Yong | Zendy; HyunJae Shin | Zendy; Ji-Eun Lee | Zendy

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Wheatgrass extract inhibits hypoxia-inducible factor-1-mediated epithelial-mesenchymal transition in A549 cells

Author(s) -

Nam Yong,

HyunJae Shin,

Ji-Eun Lee

Publication year - 2017

Publication title -

nutrition research and practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.506

H-Index - 34

eISSN - 2005-6168

pISSN - 1976-1457

DOI - 10.4162/nrp.2017.11.2.83

Subject(s) - hypoxia (environmental) , epithelial–mesenchymal transition , microbiology and biotechnology , mesenchymal stem cell , hypoxia inducible factors , a549 cell , transition (genetics) , chemistry , cancer research , biology , apoptosis , biochemistry , gene , oxygen , organic chemistry

Epithelial-mesenchymal transition (EMT) is involved in not only cancer development and metastasis but also non-cancerous conditions. Hypoxia is one of the proposed critical factors contributing to formation of chronic rhinosinusitis or nasal polyposis. Wheatgrass ( Triticum aestivum ) has antioxidant, anti-aging, and anti-inflammatory effects. In this study, we analyzed whether wheatgrass has an inhibitory effect on the EMT process in airway epithelial cells.

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