Open AccessCurcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion
Author(s) -
Jin Ah Cho,
Eun Mi Park
Publication year - 2015
Publication title -
nutrition research and practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.506
H-Index - 34
eISSN - 2005-6168
pISSN - 1976-1457
DOI - 10.4162/nrp.2015.9.2.117
Subject(s) - curcumin , endoplasmic reticulum , xbp1 , microbiology and biotechnology , tight junction , thapsigargin , apoptosis , inflammation , cholera toxin , unfolded protein response , biology , chemistry , pharmacology , immunology , biochemistry , rna , rna splicing , gene
Curcumin, a major component of the Curcuma species, contains antioxidant and anti-inflammatory properties. Although it was found to induce apoptosis in cancer cells, the functional role of curcumin as well as its molecular mechanism in anti-inflammatory response, particularly in intestinal cells, has been less investigated. The intestine epithelial barrier is the first barrier and the most important location for the substrate coming from the lumen of the gut.