Deterministic chaos and wash-out determination in crossover trials | Zendy

Tomasz Grabowski | Zendy; Shayne C. Gad | Zendy; J.J. Jaroszewski | Zendy; Pieter JM Guelen | Zendy

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Deterministic chaos and wash-out determination in crossover trials

Author(s) -

Tomasz Grabowski,

Shayne C. Gad,

J.J. Jaroszewski,

Pieter JM Guelen

Publication year - 2016

Publication title -

international journal of pharmacokinetics

Language(s) - English

Resource type - Journals

eISSN - 2053-0854

pISSN - 2053-0846

DOI - 10.4155/ipk.16.1

Subject(s) - chaos (operating system) , crossover , pharmacokinetics , product (mathematics) , crossover study , mathematics , chaos theory , computer science , statistics , econometrics , pharmacology , medicine , artificial intelligence , pathology , geometry , computer security , alternative medicine , placebo , chaotic

Background: Key elements of crossover studies are the determination of the wash-out (clearance) period. The purpose of this work is an attempt to implement and justify the use of deterministic chaos theory for estimating the wash-out value and reference the obtained values to the currently applicable rules. Results/methodology: The elliptical model of drug wash-out was presented to prove the hypothesis. Pharmacokinetic profiles were used for the analysis, obtained from healthy subjects during 12 studies. Conclusion: On the grounds of these calculations it may be concluded that the pharmacokinetics of xenobiotics, such as drugs, is a product of deterministic chaos.

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