The Synergistic Effect of Hydroalcoholic Extracts of Origanum Vulgare , Hypericum Perforatum and Their Active Components Carvacrol and Hypericin Against Staphylococcus Aureus | Zendy

Mahmoud Bahmani | Zendy; Morovat Taherikalani | Zendy; Mojtaba Khaksarian | Zendy; Mahmoud RafieianKopaei | Zendy; Behnam Ashrafi | Zendy; Mohammadreza Nazer | Zendy; Setareh Soroush | Zendy; Naser Abbasi | Zendy; Marzieh Rashidipour | Zendy

Open Access

The Synergistic Effect of Hydroalcoholic Extracts of Origanum Vulgare , Hypericum Perforatum and Their Active Components Carvacrol and Hypericin Against Staphylococcus Aureus

Author(s) -

Mahmoud Bahmani,

Morovat Taherikalani,

Mojtaba Khaksarian,

Mahmoud RafieianKopaei,

Behnam Ashrafi,

Mohammadreza Nazer,

Setareh Soroush,

Naser Abbasi,

Marzieh Rashidipour

Publication year - 2019

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2018-0096

Subject(s) - hypericin , carvacrol , hypericum perforatum , origanum , hypericum , staphylococcus aureus , traditional medicine , chemistry , minimum inhibitory concentration , antimicrobial , biology , microbiology and biotechnology , pharmacology , food science , medicine , essential oil , bacteria , genetics

Aim: This study was designed to evaluate the synergistic activities of hydroalcoholic extracts of medicinal plants Origanum vulgare and Hypericum perforatum and their active components, carvacrol and hypericin against Staphylococcus aureus . Methods: The synergistic effects of the plants, as well as carvacrol and hypericin, were examined using a checkered method against S. aureus (ATCC 12600). Results: A fractional inhibitory concentration of 0.5 was obtained for combination of O. vulgare and H. perforatum and 0.49 for combination of the active ingredients carvacrol and hypericin, both of which indicated a synergistic effect. Conclusion: This preliminary evaluation demonstrated a synergistic property of O. vulgare and H. perforatum extracts in treating S. aureus infection. This study indicates that combination of the plants, as well as combination of carvacrol and hypericin, might be used as a new antibacterial strategy against S. aureus .

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