Recent Advances in the Discovery of Small-Molecule Inhibitors of HIV-1 Integrase | Zendy

Eungi Choi | Zendy; Jayapal Reddy Mallareddy | Zendy; Dai Lu | Zendy; Srikanth Kolluru | Zendy

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Recent Advances in the Discovery of Small-Molecule Inhibitors of HIV-1 Integrase

Author(s) -

Eungi Choi,

Jayapal Reddy Mallareddy,

Dai Lu,

Srikanth Kolluru

Publication year - 2018

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2018-0060

Subject(s) - integrase , reverse transcriptase , human immunodeficiency virus (hiv) , drug discovery , viral replication , virology , biology , integrase inhibitor , computational biology , genome , drug resistance , protease , enzyme , genetics , virus , bioinformatics , gene , viral load , antiretroviral therapy , rna , biochemistry

AIDS caused by the infection of HIV is a prevalent problem today. Rapid development of drug resistance to existing drug classes has called for the discovery of new targets. Within the three major enzymes (i.e., HIV-1 protease, HIV-1 reverse transcriptase and HIV-1 integrase [IN]) of the viral replication cycle, HIV-1 IN has been of particular interest due to the absence of human cellular homolog. HIV-1 IN catalyzes the integration of viral genetic material with the host genome, a key step in the viral replication process. Several novel classes of HIV IN inhibitors have been explored by targeting different sites on the enzyme. This review strives to provide readers with updates on the recent developments of HIV-1 IN inhibitors.

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