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Aim:  In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against  Cryptococcus  spp. and  Candida albicans .    Methods:  The ability of CHT to act in biofilm and also to interfere with  C. albicans  adhesion was evaluated, as well as the efficiency of the CHT in cryptococcosis and candidiasis invertebrate and murine models.    Results & conclusion:  In the present work we verified that CHT is found to inhibit  Cryptococcus  and  C. albicans  affecting biofilm in both and inhibited adhesion of  Candida  to human buccal cells. When we evaluated  in vivo , CHT prolonged survival of  Galleria mellonella  after infections with  Cryptococcusgattii ,  Cryptococcusneoformans  or  C. albicans  and promoted a reduction in the fungal burden to the organs in the murine models. These results demonstrate CHT therapeutic potential.

A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models