Survival and glycemic control outcomes among patients with coexisting pancreatic cancer and diabetes mellitus | Zendy

Nina J. Karlin | Zendy; Shailja B Amin | Zendy; Heidi E. Kosiorek | Zendy; Matthew Buras | Zendy; Patricia M Verona | Zendy; Curtiss B. Cook | Zendy

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Survival and glycemic control outcomes among patients with coexisting pancreatic cancer and diabetes mellitus

Author(s) -

Nina J. Karlin,

Shailja B Amin,

Heidi E. Kosiorek,

Matthew Buras,

Patricia M Verona,

Curtiss B. Cook

Publication year - 2018

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2017-0144

Subject(s) - pancreatic cancer , glycemic , medicine , diabetes mellitus , hazard ratio , gastroenterology , cancer , survival analysis , oncology , insulin , endocrinology , confidence interval

Aim: We aimed to determine the effect of diabetes mellitus (DM) on survival in pancreatic cancer and effects of pancreatic cancer on glycemic control in DM. Materials & methods: Patients with pancreatic cancer from 2007 to 2015, with and without DM, were matched 1:1. We compared characteristics between the groups and assessed 2-year survival with Kaplan–Meier analysis. Results: In patients with DM, hemoglobin A 1c decreased significantly over time (p = 0.01). In survival analysis, 2-year overall survival estimates were 15% (95% CI: 8–24%) for DM patients versus 26% (95% CI: 17–36%) for non-DM patients (p = 0.55). The hazard ratio for matched pairs was 1.15 (95% CI: 0.75–1.77; p = 0.51). Conclusion: DM did not decrease survival in pancreatic cancer. Pancreatic cancer did not affect glycemic control.

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